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Chemiluminescence from macrophages and monocytes.

Authors
Castranova-V; Lee-P; Ma-JY; Weber-KC; Pailes-WH; Miles-PR
Source
Cellular Chemiluminescence 1987; :3-19
Link
NIOSHTIC No.
00183281
Abstract
The characteristics of chemiluminescence in alveolar macrophages, peritoneal macrophages, and blood monocytes were reviewed with regard to the monitoring of the phagocytic process. The production of chemiluminescence was associated with an increase in oxygen consumption and the release of reactive forms of oxygen including the superoxide anion and hydrogen-peroxide. Topics discussed included the methods for the measurement of chemiluminescence from peritoneal macrophages, alveolar macrophages, and blood monocytes; sources of chemiluminescence in alveolar macrophages and the role of reactive forms of oxygen in zymosan stimulated chemiluminescence; the effect of luminol in enhancing the amount of chemiluminescence generated from alveolar macrophages; the relationship between species, response, and stimulant with regard to the differential requirement for opsinization for the particulate induced activation of chemiluminescence from alveolar macrophages; the enhancement of alveolar macrophage chemiluminescence by in-vitro exposure to surfactant; and the adverse effects of bronchodilators on chemiluminescence derived from alveolar macrophages.
Keywords
Cell-metabolism; Blood-cells; Pulmonary-system; Enzymatic-effects; Oxidative-processes; Airborne-particles; Phagocytic-activity
Publication Date
19870101
Fiscal Year
1987
NTIS Accession No.
NTIS Price
NIOSH Division
DRDS
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system;
Source Name
Cellular Chemiluminescence
State
WV; FL
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