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Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction.

Authors
Welch-LS; Schrader-SM; Turner-TW; Cullen-MR
Source
Am J Ind Med 1988 Nov; 14(5):509-526
NIOSHTIC No.
00183119
Abstract
Efforts were made to determine whether exposures to 2-ethoxyethanol (110805) (2-EE) or 2-methoxyethanol (109864) (2-ME) while employed as a painter at a shipyard had any effect on male reproduction. Semen samples were collected from 73 painters and 40 comparisons. These samples were analyzed for pH, volume, turbidity, liquidity, viability by stain exclusion and hypoosmotic stress, sperm density and count per ejaculate, motility, morphology and morphometry. Serum samples were analyzed for testosterone, follicular stimulating hormone and luteinizing hormone. Analysis of the work environment indicated the men were exposed to 2-EE at a time weighted average (TWA) concentration of 0 to 80.5mg/m3 with a mean of 9.9mg/m3 and to 2-ME at a TWA of 0 to 17.7mg/m3 with a mean of 2.6mg/m3. Increased prevalence of oligospermia and azoospermia was noted among the painters as well as an increased odds ratio for a lower sperm count per ejaculate. The finding that ethylene-glycol ethers affect reproductive function was consistent with results of earlier experiments and epidemiologic studies.
Keywords
NIOSH-Author; Ethanols; Inhalants; Reproductive-system-disorders; Shipyard-workers; Shipbuilding-industry; Organic-solvents; Solvent-vapors; Fertility; Reproductive-effects; Author Keywords: infertility; oligospermia; azoospermia; 2-ethoxyethanol; 2-methoxyethanol; occupational disease
Contact
Dr. Laura S. Welch, Department of Medicine, George Washington University School of Medicine, 2150 Pennsylvania Ave., N.W., Washington, DC 20037
CODEN
AJIMD8
CAS No.
110-80-5; 109-86-4
Publication Date
19881101
Document Type
Journal Article
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0271-3586
NIOSH Division
DBBS
Source Name
American Journal of Industrial Medicine
State
DC; OH; CT
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