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Gas and particle deposition in tracheobronchial airways.

Authors
Cohen-BS
Source
Institute of Environmental Medicine, New York University Medical Center, New York, New York, 1987 Aug; :1-14
Link
NIOSHTIC No.
00182778
Abstract
Gas and aerosol deposition efficiency in lung airways of humans and animals were investigated under two different airflow patterns: steady inspiratory flow and pulsatile inspiratory flow. The differences and similarities between deposition patterns in the human dichotomous branching tracheobronchial tree and the canine monopodial branching were documented. Hollow airway casts were prepared from whole lungs obtained at autopsy from a 45 year old man and from a mixed breed dog. Morphometric measurements were made on the casts through the fifth generation for all airway branches and to the terminal airways along a major branch path, a minor branch path, and a path which alternately selects major and minor branches. Flow measurements were made for inspiratory flow and pulsatile inspiratory flow. Pulsatile inspiratory flow was found to be more realistic than steady flow in this model. The hollow airway cast system was evaluated for use in investigations of patterns of gas transfer to airway surfaces.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Aerosol-particles; Airway-obstruction; Airway-resistance
Contact
Environmental Medicine New York Univ Medical Center 550 First Avenue New York, N Y 10016
Publication Date
19870801
Document Type
Final Grant Report
Funding Amount
97200.
Funding Type
Grant
Fiscal Year
1987
NTIS Accession No.
PB89-129878
NTIS Price
A03
Identifying No.
Grant-Number-K01-OH-00022
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Institute of Environmental Medicine, New York University Medical Center, New York, New York
State
NY
Performing Organization
New York University, New York, New York
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