Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Percutaneous absorption of hydroquinone in gumans: effect of 1- dodecylazacycloheptan-2-one (Azone) and the 2-ethylhexyl ester of 4- (dimethylamino) benzoic acid (Escalol 507).

Authors
Bucks-DA; McMaster-JR; Maibach-RH
Source
Departments of Dermatology and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California, 1987 Dec; :1-20
Link
NIOSHTIC No.
00182770
Abstract
The effects of a penetration enhancer, 1-dodecylazacycloheptan-2-one (Azone) and a sunscreen, the 2-ethylhexyl ester of 4-(dimethylamino)- benzoic-acid (Escalol 507) on the percutaneous absorption of hydroquinone (123319) were studied. Volunteers each received a single 100 microliter dose of carbon-14 labeled hydroquinone module by topical application to forehead skin. Module 1 contained Azone and Escalol-507, module 2 contained Azone, module 3 contained Escalol-507 and module 4 contained no Azone or Escalol-507. Average percutaneous absorption of hydroquinone as estimated from the urinary elimination data was 35, 66, 26, and 57 percent for modules 1, 2, 3, and 4, respectively. Peak elimination was noted within the first 12 hours and elimination was complete within 5 days from application. Escalol-507 (3 percent by weight) significantly inhibited the absorption. Azone (0.5 percent by weight) did not significantly increase absorption either alone or with Escalol-507 present. The authors suggest that if Azone were used at higher concentrations or in a different vehicle system, the findings might be different.
Keywords
NIOSH-Grant; Dermatitis; Skin-exposure; Skin-absorption; Antioxidants; Pharmaceuticals; Humans
Contact
Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
CAS No.
123-31-9
Publication Date
19871201
Document Type
Final Grant Report
Funding Amount
93049
Funding Type
Grant
Fiscal Year
1988
NTIS Accession No.
PB89-129985
NTIS Price
A03
Identifying No.
Grant-Number-K01-OH-00017
NIOSH Division
OEP
Priority Area
Dermatitis
Source Name
Departments of Dermatology and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California
State
CA
Performing Organization
University of California San Francisco, San Francisco, California
TOP