Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The detection of ethylene dibromide and 2-ethoxyethanol in the blood and semen of rabbits.

Authors
Oudiz-DJ
Source
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, 1984 Sep; :1-8
Link
NIOSHTIC No.
00182748
Abstract
The possibility of monitoring the concentration of toxicants in semen was examined using 16 male Dutch-belted-rabbits given either 1000mg/kg of 2-ethoxyethanol (110805) (EE) or 22mg/kg ethylene- dibromide (106934) (EDB) by gavage. Blood concentrations for EE peaked between 1 and 1.5 hours after administration and then rapidly declined. Semen levels of EE closely paralleled those in the blood, but they were consistently higher in the semen. The mean blood concentrations for EDB peaked in 30 minutes and appeared to go through a distribution phase before the terminal dieaway. Levels of EDB in the semen were extremely variable. The blood and semen concentrations of EDB did not show a clear relationship. EDB itself was completely metabolized and not detected in the urine. EDB may have caused organ changes. Due to the unpredictability of the semen concentrations, the authors conclude that blood level concentrations of EDB should not be taken as indicative of what the semen levels are at the same time.
Keywords
NIOSH-Grant; Reproductive-system-disorders; Metabolic-study; Tissue-distribution
Contact
Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, Ohio 45267
CAS No.
110-80-5; 106-93-4
Publication Date
19840901
Document Type
Final Grant Report
Funding Amount
20998
Funding Type
Grant
Fiscal Year
1984
NTIS Accession No.
PB89-129894
NTIS Price
A02
Identifying No.
Grant-Number-R03-OH-01859
NIOSH Division
OEP
Priority Area
Reproductive-system-disorders
Source Name
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
TOP