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Coal liquids: skin toxicity and mutagenicity studies.

Authors
Bickers-DR
Source
Department of Dermatology, Case Western Reserve University, Cleveland, Ohio. 1985 Jan; :1-9
Link
NIOSHTIC No.
00182720
Abstract
Summaries were included in this final progress report of the various research publications generated during the study of the effects of coal-tar (8007452) on xenobiotic metabolism in the skin. Specifically information was sought concerning the activity of aryl- hydrocarbon-hydroxylase (AHH). Neonatal rats were used to study the enzyme activity in epidermal, dermal, and other bodily tissues. Significant induction of AHH was noted in the tissues following topical application of benzo(a)pyrene (50328) (BP) or the Aroclor- 1254 (11097691) mixture. Skin enzymes demonstrated a greater activity than other extrahepatic tissues. Primary results of research into the induction of skin and liver AHH activities following topical application of coal tar were reported along with the results of coal tar application and subsequent induction of hepatic cytosolic glutathione-S-transferase and microsomal epoxide- hydrolase and aminopyrine N-demethylase activities. The drug metabolizing enzyme activity and the hemeprotein cytochrome-P-450 and epoxide-hydrolase activities were compared in skin, epidermal, and dermal tissues following coal tar administration and the enzyme activities in the liver, lung, kidney, and intestine were also examined.
Keywords
NIOSH-Grant; Dermatitis; Liver-microsomal-enzymes; Chlorinated-hydrocarbons; Aromatic-hydrocarbons; Coal-tar-pitch; Coal-workers; Coal-products; Skin-exposure; Laboratory-animals
Contact
Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
CAS No.
8007-45-2; 50-32-8; 11097-69-1
Publication Date
19850101
Document Type
Final Grant Report
Funding Amount
267904
Funding Type
Grant
Fiscal Year
1985
NTIS Accession No.
PB89-130769
NTIS Price
A02
Identifying No.
Grant-Number-R01-OH-01149
NIOSH Division
OEP
Priority Area
Dermatitis
Source Name
Department of Dermatology, Case Western Reserve University, Cleveland, Ohio
State
OH
Performing Organization
Case Western Reserve University, Cleveland, Ohio
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