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Direct sampling of organic solvents in expired breath with a new solid sorbent sampling device.

Authors
Glaser-RA; Arnold-JE; Shulman-SA
Source
Scand J Work, Environ & Health 1988 May/Jun; 14(Suppl 1):63-65
NIOSHTIC No.
00181599
Abstract
A newly developed solid sorbent device for sampling organic solvents in expired air was tested. The sampler operated on the same principle as an air purifying respirator. Mixed exhaled air inside the device was sampled from the mainstream on 45 millimeter wafers of charcoal cloth sorbent or from the sidestream on Tenax-TA sorbent. Six male volunteers were exposed to 75 parts per million m- xylene (108383) (xylene) for 4 hours for sampler evaluation. After each exposure, breath samples were collected up to 240 minutes after exposure and analyzed for xylene and carbon-dioxide by gas chromatography. End/expired breaths were sampled with gas bags for comparison purposes. Linear regression analysis of the data obtained by both sampling methods showed that the xylene concentrations could be fit to a quadratic exponential decay function. The mean ratio of xylene concentrations obtained by the charcoal cloth to gas bag sampling was 0.58. The mean ratio for carbon-dioxide was 0.61. For Tenax sampling, the mean ratio of xylene concentrations obtained by the sorbent to gas bag sampling was 0.43. A consistent ratio for carbon-dioxide concentrations could not be obtained. The combined data could be fit to a three component pharmacokinetic model. The authors conclude that mainstream sampling of exhaled air with charcoal cloth in the analysis of organic solvents is as precise as sampling end/expired air with gas bags.
Keywords
NIOSH-Author; Humans; Aromatic-hydrocarbons; Organic-solvents; Mathematical-models; Pharmacodynamics; Adsorbents; Sampling-methods
CODEN
SWEHDO
CAS No.
108-38-3
Publication Date
19880501
Document Type
Journal Article
Fiscal Year
1988
NTIS Accession No.
NTIS Price
ISSN
0355-3140
Source Name
Scandinavian Journal of Work, Environment and Health
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