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Experimental nitrous oxide exposure as a model system for evaluating neurobehavioral tests.

Authors
Mahoney-FC; Moore-PA; Baker-EL; Letz-R
Source
Toxicology 1988 May; 49(2/3):449-457
NIOSHTIC No.
00181407
Abstract
The effect of nitrous-oxide (10024972) on neurobehavioral test performance was evaluated. Fifteen white males, 24 to 34 years old, were exposed to 0, 20, or 40 percent nitrous-oxide. They were then administered a computerized battery of neurobehavioral tests that evaluated continuous performance, hand/eye coordination, serial digit learning, symbol digit substitution, pattern recognition, pattern memory, choice reaction time, finger tapping, and mood. Performance was scored using 0 percent nitrous-oxide exposure as the baseline. The 20 percent exposure significantly impaired performance on the symbol digit and finger tapping tests. A marginally significant decrement in continuous performance test response latency was also seen. There was a significant effect on the confusion items in the Mood scales test. Nitrous-oxide at 40 percent impaired performance on all tests. The impairments were significant for all tests except the symbol digit learning task. Confusion on the Mood scales was significantly at this dose as well. The authors conclude that their findings agree with those of previous studies. Nitrous-oxide appears to be a useful standard for comparing the sensitivity of neurobehavioral tests. The computerized neurobehavioral test battery, particularly the Switching Attention task, is a valid technique for documenting functional status of the central nervous system.
Keywords
NIOSH-Author; Humans; Laboratory-testing; Inhalation-studies; Nitrogen-oxides; Behavioral-testing; Mental-processes; Dose-response; Task-performance
CODEN
TXCYAC
CAS No.
10024-97-2
Publication Date
19880501
Document Type
Journal Article
Fiscal Year
1988
NTIS Accession No.
NTIS Price
Issue of Publication
2/3
ISSN
0300-483X
Source Name
Toxicology
State
MA; PA; GA
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