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Mucociliary transport and particle clearance in the human tracheobronchial tree.

Authors
Yu-CP; Hu-JP; Leikauf-G; Spektor-D; Lippmann-M
Source
Faculty of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, New York, 1988 Jun; :1-4
Link
NIOSHTIC No.
00181319
Abstract
A compartmental model to describe mucociliary transport and particle clearance in the tracheobronchial trees was described. A method was proposed for determining the mucociliary transport rate as a function of the airway depth from the retention curve directly. Each airway generation was represented by an escalator. For Weibel's lung model there were 17 airway generations in the tracheobronchial tree. The subject performed a series of respiratory mechanical function tests prior to exposure to a monodisperse ferric-oxide aerosol tagged with technetium-99m. Thoracic retention measurements were started 5 minutes after inhalation and continued throughout the next 8 hours with an additional measurement taken the following day. Mucus velocities in millimeters/minute tended to decrease with the value increase of the generation number, but was nearly a constant between generation 7 and 14. The model was simple and appeared to describe the physical process well. Appropriate adjustments of the subject's airway dimensions were needed to further develop the model so that a single set of values of mucus velocity can be determined for several retention curves using different size particles and breathing patterns.
Keywords
NIOSH-Grant; Airborne-particles; Dust-inhalation; Pulmonary-system-disorders; Mucous-membranes; Bronchial-asthma
Contact
Engineering Science S U N Y - at Buffalo Dept of Engineering Science Buffalo, N Y 14214
Publication Date
19880601
Document Type
Final Grant Report
Funding Amount
215528
Funding Type
Grant
Fiscal Year
1988
NTIS Accession No.
PB88-247846
NTIS Price
A01
Identifying No.
Grant-Number-R01-OH-00923
NIOSH Division
OEP
Source Name
Faculty of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, New York
State
NY
Performing Organization
State University of New York at Buffalo, Buffalo, New York
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