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Protocol for Urine Monitoring Study of Workers Exposed to 4,4'- Methylene Dianiline.

Authors
Boeniger-M
Source
NIOSH 1984 Aug:65 pages
Link
NIOSHTIC No.
00181311
Abstract
Efforts were directed toward characterizing worker exposure to 4,4'- methylene-dianiline (101779) (4,4'-MDA) and evaluate the usefulness of collecting worker urine samples to assess exposure to 4,4'-MDA on the job. Industrial uses for 4,4'-MDA include as a curing agent for epoxy resin laminates, in industrial coatings for abrasion and corrosion resistance, in the formulation of high temperature polyester-imide wire coating enamels, in the production of chemically related derivatives, as a coreactant with polyurethanes, and in the production of electrical circuit boards. A review of pharmacokinetic studies was included, along with considerations of importance in biological monitoring, study site and worker selection factors, identification of biological variables, choosing a nonexposed comparison group, survey procedures, sampling methods, environmental sampling techniques, urinalysis methods and sample collection and processing, analytical procedures used for the air, wipe, and dermal samples, statistical methods used for the field data analysis, quality assurance procedures, safety of the investigators during the study, records management and data reporting.
Keywords
NIOSH-Author; Carcinogens; Arylamines; Cancer-rates; Urine-chemistry; Curing-compounds; Epoxy-compounds; Sampling-methods;
CAS No.
101-77-9;
Publication Date
19840801
Fiscal Year
1984
NTIS Accession No.
PB88-247291
NTIS Price
A05
NIOSH Division
DSHEFS;
Source Name
Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 65 pages, 31 references
State
OH;
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