Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Neoplastic effects of vinyl chloride in mouse lung - lower doses and short-term exposure.

Authors
Suzuki-Y
Source
Environmental Sciences Laboratory, Mount Sinai School of Medicine, City University of New York 1982 Nov; :1-20
Link
NIOSHTIC No.
00181308
Abstract
Effects of exposure to 1 to 600 parts per million (ppm) vinyl- chloride (75014) over 4 week periods were investigated in 220 male CDI-Charles-River-mice. Exposure was for 6 hours/day, 5 days/week. At 12 weeks, 88.8 percent of those exposed to 600ppm and 66.6 percent of those exposed to 300ppm were found to have alveologenic tumors. In the 300ppm group these were all single tumors whereas the 600ppm group all had multiple tumors. A dose/response relationship was noted for tumor incidence as well as a dose related latency period. Dose and the recovery period after exposure seem to be the factors which determine the incidence of multiple alveologenic tumors. Larger tumors appeared to occur in the group receiving the higher dose levels and also in animals whose recovery period was longer. Spontaneous alveologenic tumors occurred in six animals. Histopathological examination revealed no evidence that tumor cells were derived from Clara cells of the terminal bronchioles. Neoplastic cells in both the tubulopapillary and adenomatous forms of the pulmonary tumors possessed all or some of the ultrastructural characteristics of type-II alveolar cells. Other tumors included hemangiosarcomas in the subcutaneous connective tissue of the ear (10ppm, 29 weeks after exposure) and the liver (600ppm, 65 weeks after exposure). The authors concluded that type-II alveolar cells are the most sensitive in mice to the neoplastic potential of vinyl-chloride exposure.
Keywords
NIOSH-Grant; Laboratory-animals; Carcinogenesis; Tumorigenesis; Pulmonary-system-disorders; Lung-disorders; Liver-disorders; Liver-cancer; Lung-cancer;
Contact
Community Medicine MT Sinai School of Medicine Fifth Avenue and 100Th Street New York, N Y 10029
CAS No.
75-01-4
Publication Date
19821130
Document Type
Final Grant Report
Funding Amount
8639931
Funding Type
Grant
Fiscal Year
1983
NTIS Accession No.
PB88-252390
NTIS Price
A03
Identifying No.
Grant-Number-T15-OH-07125
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Environmental Sciences Laboratory, Mount Sinai School of Medicine, City University of New York
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
TOP