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Biologic activity of lipid coated quartz dust.

Authors
Tuma-J
Source
Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania 1971 Mar; :1-4
Link
NIOSHTIC No.
00181266
Abstract
The biological activity of quartz (14808607) dust coated with endogenous lipids was investigated. The theory under study was that the lipidic coating would render the quartz particles nonwettable, and therefore biologically inert. One gram of quartz dust was dispersed in 25 milliliters of 0.5 percent solution of lipids in chloroform and dried. Lipid coated and uncoated dust was dispersed in water and injected into rats intratracheally. The animals were sacrificed 2 days, 6 months or 10 months following injection. No significant differences were found in the content of silica (7631869) and hydroxyproline in the lungs of rats injected with lipid coated or uncoated dust. Lymph node silica content was also similar between the two treatment groups. The quality or quantity of the silicotic nodulations induced by the lipid coated silica and by the noncoated silica were similar. The authors concluded that the treatment of quartz dust with endogenous lipids did nothing to reduce the biological activity of this mineral in its ability to produce silicotic nodulations and collagen in rat lungs. The clearing of silica dust from the lungs was also not changed by the treatment.
Keywords
NIOSH-Grant; Laboratory-animals; Mineral-dusts; Pulmonary-system-disorders; Lung-tissue; Lung-burden; Silica-dusts; Silicosis; Lymphatic-system
Contact
Research Laboratory Industrial Hygiene Fdn 5231 Centre Avenue Pittsburgh, PA 15232
CAS No.
14808-60-7; 7631-86-9
Publication Date
19710303
Document Type
Final Grant Report
Funding Amount
16214
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
PB88-248307
NTIS Price
A01
Identifying No.
Grant-Number-R01-OH-00333
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania
State
PA
Performing Organization
Industrial Health Foundation, Pittsburgh, Pennsylvania
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