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Mechanism of occupational leukoderma.

Authors
Menter-JM
Source
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-001556, 1986 Oct; :1-9
Link
NIOSHTIC No.
00181250
Abstract
The binding and redox interactions of selected phenolic and catecholic compounds of widely varying potency were studied with model synthetic melanins, melanin-tyrosinase depigmenter (DP) complexes and with melanoproteins extracted from C-57-BL-6-black- mice. Using ferricyanide as an electron acceptor it was demonstrated that DP melanin binding can lead to alterations in electron transfer kinetics, and that the magnitude of such alterations may be roughly correlated with depigmenting potency. Attempts were made to induce hair depigmentation by local subcutaneous or intradermal injection of DPs into black-mice. A possible correlation was sought between DP potency and the behavior of one or more component interactions. The results of these studies will help in early detection and prediction of environmental depigmenters, attainment of a reliable regimen for effecting controlled depigmentation, effective use of the appropriate DP's as chemotherapeutic agents in malignant melanoma, and determination of mechanistic similarities and differences between occupational depigmentation and vitiligo.
Keywords
NIOSH-Grant; Laboratory-animals; Pigmentation; Pigments; Pigmentation-disorders; Skin-disorders; Skin-exposure
Contact
Biochemistry Morehouse School of Medicine 830 Westrview Drive, SW Atlanta, Georgia 30314
Publication Date
19861020
Document Type
Final Grant Report
Funding Amount
149944
Funding Type
Grant
Fiscal Year
1987
NTIS Accession No.
PB88-247986
NTIS Price
A02
Identifying No.
Grant-Number-R01-OH-001556
Priority Area
Dermatitis
Source Name
National Institute for Occupational Safety and Health
State
GA
Performing Organization
Morehouse School of Medicine, Atlanta, Georgia
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