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Hair as a monitor of toxic chemicals exposure.

Authors
Jones-PF; Adams-S; Baumgartner-WA
Source
Aerospace Corporation, Los Angeles, California, Aerospace Report No. ATR-0082(7950)-1, 1982 Aug; :1-9
Link
NIOSHTIC No.
00181248
Abstract
The possibility of using hair analysis as a monitor of exposure to hydrazines and polychlorinated-biphenyls (1336363) (PCBs) was investigated. Two female Hartley-guinea-pigs injected with 0.6 milligrams (mg) of Aroclor-1254 (11097691) had analyzable concentrations of the PCB in their hair. Analysis was made using glass capillary gas chromatography with an electron capture detector. The levels ranged from 10 picograms/milligram (pg/mg) of Aroclor-1254 in washed hair to 100pg/mg in unwashed hair. Female Fischer-344-rats injected intraperitoneally with 60mg/kg unsymmetrical dimethyl-hydrazine (57147) (UDMH), 10mg/kg monomethyl- hydrazine (60344) (MMH) and/or 10mg/kg hydrazine (302012) did not have detectable amounts of these chemicals in their hair at 14, 30 or 42 days after injection. The hair samples did take up the hydrazines when suspended above solutions of the test compounds. The authors concluded that analyzing the PCB content of hair may be useful in providing a history of on the job PCB exposure.
Keywords
NIOSH-Grant; Biological-monitoring; Environmental-contamination; Environmental-pollution; Insecticides; Pesticides; Chromatographic-analysis; Laboratory-animals
Contact
Analytical Sciences Aerospace Corporation 2350 E EL Segundo EL Segundo, Calif 90245
CAS No.
1336-36-3; 11097-69-1; 57-14-7; 60-34-4; 302-01-2
Publication Date
19820831
Document Type
Final Grant Report
Funding Amount
117725
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
PB88-252689
NTIS Price
A02
Identifying No.
Grant-Number-R01-OH-01030
NIOSH Division
OEP
Source Name
Aerospace Corporation, Los Angeles, California, Aerospace Report No. ATR-0082(7950)-1
State
CA
Performing Organization
Aerospace Corporation, EL Segundo, California
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