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Respiratory tract irritants: mechanisms and tolerance (terminal progress report).

Authors
Alarie-Y
Source
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, Terminal Progress Report, 1981 Nov; :1-6
Link
NIOSHTIC No.
00181245
Abstract
An animal bioassay system was developed to evaluate airborne chemicals of industrial importance which cause sensory irritation in humans; a model was calibrated for the prediction of safe levels of exposure in industry. This model permitted the evaluation of mixtures of airborne chemicals and could be calibrated to predict human response to such mixtures. The development of tolerance to airborne chemical irritants and the cumulative effects of airborne chemical irritants could be investigated with this bioassay system. The development of a valid animal model for pulmonary hypersensitivity and the application of such findings in workers was initiated. Through an animal bioassay which was developed the interaction of inhaled chemicals with DNA can be studied in alveolar macrophages.
Keywords
NIOSH-Grant; Inhalation-studies; Laboratory-animals; Bioassays; Eye-irritants; Lung-irritants; Respiratory-irritants
Contact
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
Publication Date
19811101
Document Type
Final Grant Report
Funding Amount
332059
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
PB88-252614
NTIS Price
A02
Identifying No.
Grant-Number-R01-OH-00367
NIOSH Division
OEP
Source Name
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, Terminal Progress Report
State
PA
Performing Organization
University of Pittsburgh, Pittsburgh, Pennsylvania
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