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Exposure to mixtures of airborne contaminants.

Authors
Smith-FA
Source
University of Rochester School of Medicine and Dentistry, Rochester, New York, Final Progress Report 1977 Jan; :1-25
Link
NIOSHTIC No.
00181032
Abstract
Attempts were made to characterize the response of laboratory animals to particulates carried in the air and to gaseous airborne pollutants, as a preliminary step towards investigation of the effects of a mixture of gaseous and particulate pollutants. Guinea- pigs were exposed fluoride (16984488) at 1.2mg/m3 as fluorspar (7789755) dust of respirable size for 16 weeks or to fluoride at 3.3mg/m3 as hydrogen-fluoride (7664393). The fluoride concentrations were increased in plasma, femur, and feces. Hydrogen- fluoride exposure also increased fluoride levels in the bile and urine. The number of alveolar macrophages was increased on dust exposure whereas the incidence of patchy pneumonitis was decreased on hydrogen-fluoride exposure. Pulmonary edema was produced but only lasted 2 days. All these changes returned to normal after exposure to the fluoride agents was terminated, with the exception of skeletal fluoride levels. No evidence of continuing harmful effects was noted. Studies remain to be conducted of animals exposed to the two pollutants, particulates and gaseous forms, simultaneously.
Keywords
NIOSH-Grant; Body-distribution; Fluorides; Fluoride-compounds; Airborne-particles; Toxic-gases; Inhalation-studies; Respirable-dust; Pulmonary-system; Laboratory-animals
Contact
Radiation Biology & Biophysics University of Rochester Dept of Rad Biol & Biophysics Rochester, N Y 14642
CAS No.
16984-48-8; 7789-75-5; 7664-39-3
Publication Date
19770101
Document Type
Final Grant Report
Funding Amount
107436
Funding Type
Grant
Fiscal Year
1977
NTIS Accession No.
PB88-247697
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00472
NIOSH Division
OEP
Priority Area
Pulmonary-system
Source Name
University of Rochester School of Medicine and Dentistry, Rochester, New York, Final Progress Report
State
NY
Performing Organization
University of Rochester, Rochester, New York
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