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Methyl methacrylate induced changes in CNS activity.

Authors
Innes-DL
Source
Department of Physiology and Biophysics, Temple University, Philadelphia, Pennsylvania, Terminal Progress Report 1980 Jan; :1-10
Link
NIOSHTIC No.
00181017
Abstract
Experiments were performed to determine if methyl-methacrylate (80626) (MMA) monomer vapor in air caused central nervous system (CNS) changes in exposed rats. Rats were exposed to 400 parts per million (ppm) MMA vapor for 60 minutes. The only significant changes to develop occurred in the lateral hypothalamic and ventral hippocampal nuclei. Several substudies conducted to better understand these results suggested that the changes in the hippocampal neuronal firing rates were related to the perception of the MMA odor and dependent on the presence of an intact nervous connection to the receptors in the nose. In a subchronic study animals were exposed for 2 to 10 weeks to 400ppm MMA vapor. No consistent long term changes in neuronal activity were detected. However, a decrease in neuronal activity was detected during the first week of exposure. In another study the exposure levels of MMA ranged from 50 to 800ppm. The lateral hypothalamic and ventral hippocampal nuclei responded as before, but not at the 50ppm level. From this data the author concludes that the threshold exposure concentration for the observed effects are the same as or slightly less than the current threshold limit value for MMA vapor in the workplace.
Keywords
NIOSH-Grant; Plastics-industry; Nervous-system-disorders; Inhalation-studies; Vapors; Laboratory-animals; Central-nervous-system; Toxic-effects
Contact
Physiology and Biophysics Temple University Physiology and Biophysics Dept Philadelphia, PA 19140
CAS No.
80-62-6
Publication Date
19800101
Document Type
Final Grant Report
Funding Amount
47367
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
PB88-247648
NTIS Price
A02
Identifying No.
Grant-Number-R01-OH-00740
NIOSH Division
OEP
Source Name
Department of Physiology and Biophysics, Temple University, Philadelphia, Pennsylvania, Terminal Progress Report
State
PA
Performing Organization
Temple University, Philadelphia, Pennsylvania
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