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Immune injury in occupational respiratory disease.

Authors
Burrell-R; Snyder-I
Source
Department of Microbiology, West Virginia University Medical Center, Morgantown, West Virginia, Terminal Project Report, 1980 Jan; :1-14
Link
NIOSHTIC No.
00181014
Abstract
Work on nine different research projects on immune injury in occupational respiratory disease falling under this grant was reviewed. Topics included the pulmonary activities of Thermoactinomyces-vulgaris and Micropolyspora-faeni, comparison of endotoxin/like properties of T-vulgaris and M-faeni with known enterobacterial lipopolysaccharides, evaluation of inflammatory changes induced in the lung by inhalation of M-faeni spores, cotton dust, cotton bract dust, Escherichia-coli, and purified endotoxin aerosols, evaluation of the effects of inflammatory changes on respiratory immunization with soluble or particulate antigens, investigating the role of APC activation by inflammatory agents, the local and systemic cell mediated immunocompetence of lymphoid cells from unimmunized experimental animals, preparing both a soluble and a particulate form of a protein antigen for aerosol immunization, development of appropriate immunization protocols to deliver soluble and particulate antigen in equal amounts to the lower respiratory tract, and a comparison of the effect of local respiratory immunization with a soluble and particulate form of protein antigen on the induction of local and systemic cell mediated immunity.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Immunologic-disorders; Inhalation-studies; Bacterial-dusts; Laboratory-animals; Cotton-dust
Contact
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
Publication Date
19800101
Document Type
Final Grant Report
Funding Amount
289015
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
PB88-247622
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00360
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Department of Microbiology, West Virginia University Medical Center, Morgantown, West Virginia, Terminal Project Report
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
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