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Final report on the project aerosol deposition in the human respiratory system.

Authors
Yu-CP
Source
State University of New York, Buffalo, New York, 1987 Jan; :1-14
Link
NIOSHTIC No.
00181008
Abstract
Attempts were made to develop mathematical models for the deposition of aerosols in the human respiratory system. Expressions were obtained for the mean deposition efficiency for nasal inspiration, nasal expiration and mouth inspiration. A determination was made of statistical properties associated with each deposition efficiency due to intersubject and intrasubject variabilities. Expressions were then derived for head deposition with combined nose and mouth breathing. In the lung, deposition is a result primarily of impaction, sedimentation, and diffusion. While there was no adequate model for impaction, several deposition formulae for sedimentation have been derived as well as ones for diffusion. Studies have also been made of the particle charge effect, as the electrostatic image force on a particle contributes to its deposition. There is, however, a threshold charge per particles below which the particle charge has no effect on deposition. Deposition data on ultrafine particles is scarce due to the difficulties in conducting proper experiments. Studies have also been concerned with the deposition of large particles, the deposition of polydisperse aerosols, the effect of different airway structures, statistical models, and clearance in the tracheobronchial tree.
Keywords
NIOSH-Grant; Inhalation-studies; Pulmonary-system; Inhalants; Aerosol-particles; Lung-function; Particulates; Mathematical-models
Contact
Engineering Science S U N Y - at Buffalo Dept of Engineering Science Buffalo, N Y 14214
Publication Date
19870101
Document Type
Final Grant Report
Funding Amount
215528
Funding Type
Grant
Fiscal Year
1987
NTIS Accession No.
PB88-247614
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00923
NIOSH Division
OEP
Source Name
State University of New York, Buffalo, New York
State
NY
Performing Organization
State University of New York at Buffalo, Buffalo, New York
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