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Fractionation and Analysis of Asphalt Fumes for Carcinogenicity Testing.

Belinky-BR; Cooper-CV; Niemeier-RW
NIOSH 1988:119-128
Asphalt (8052424) fumes generated at two different temperatures (232 and 316 degrees-C) were fractionated and chemically characterized as part of a study on the carcinogenic effects of exposure to asphalt and coal-tar-pitch (65996932) (CTP) in kettles on roofs. A Type-III asphalt was used to generate the fumes in a 12 liter reaction flask which contained about 10 kilograms of the asphalt. The fumes were trapped in an ice water bath, followed by two dry ice/acetone traps and one impinger containing a 1:1 mixture of cyclohexane/acetone. Over a period of several weeks 6 kilograms of fume were generated, collected, combined and transferred to a separatory funnel where the condensed water was removed. The organic phase was flash evaporated and the residual solids weighed. Cyclohexane/acetone was added to give a 50 percent solution. Before fractionation the fume was filtered, flash evaporated and reconstituted in a 50/50 mixture of hexane and methyl-tert-butyl-ether. Fractionation was accomplished using preparative high performance liquid chromatography. Gravimetric analyses and infrared spectra studies were also performed. In the five fractions obtained the following compositions were identified by gas chromatography/mass spectrometry: C9 to C35 alkanes, alkylated benzenes and naphthalenes; alkylated benzothiophenes, dibenzothiophenes, benzonaphthothiophenes, phenanthrenes, and C6 to C26 olefins; alkylated phenylethanones and C2 to C11 alkylated dihydrofuranones; alkylated phenols and ketones; and C6 to C22 alkylated ketones, naphthols and phenols.
Carcinogens; Chemical-analysis; Chromatographic-analysis; Asphalt-industry; Asphalt-fumes; Tumorigenesis; Roofing-industry; Roofers;
8052-42-4; 65996-93-2;
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Conference/Symposia Proceedings;
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Proceedings of the Fourth NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, April 22-23, 1986, Rockville, Maryland, NIH Publication No. 88-2960