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Biochemical, Pharmacological and Tumorigenic Studies on a Composite of Drinking Water Carcinogens and Mutagens Utilizing Aquatic Animals.

Authors
Overstreet-RM; Hawkins-WE; Walker-WW
Source
NIOSH 1988:23-39
Link
NIOSHTIC No.
00180850
Abstract
This study was performed to determine the different reactions of various fish to carcinogenic compounds, to demonstrate the wide variety of neoplasms which can develop in fish, to demonstrate that a combination of halomethanes can induce neoplasia in fish, and to show the effect of the genotoxic compound methylazoxymethanol- acetate (592621) (MAM-Ac) in a model. Fish used in the study included the Japanese-medaka, king-cobra-guppy, sheepshead-minnow, Gulf-killifish, inland-silverside, rivulus, and fathead-minnow. The chemicals used in the study included a mixture of six trihalomethanes (THM), specifically chloroform (67663), bromodichloromethane (75274), chlorodibromomethane (124481), bromoform (75252), trichloroethylene (79016), and carbon- tetrachloride (56235). Also included were the following single compounds: vinylidene-chloride (75354), trichloroethylene, and bis(2-chloroethyl)ether (111444). The authors conclude that some small aquarium fish are good carcinogenicity models as they are sensitive to induction of a wide variety of neoplasms which have a short latency period. The fish also have a low number of spontaneous neoplasms, are cheap to maintain, and most susceptible tissues can be screened for neoplasms in one or a few microscopic slides.
Keywords
Carcinogens; Chlorinated-hydrocarbons; Mutagens; Halogenated-hydrocarbons; Environmental-contamination; Animal-studies; Halogenated-compounds; Methanes;
CAS No.
592-62-1; 67-66-3; 75-27-4; 124-48-1; 75-25-2; 79-01-6; 56-23-5; 75-35-4; 111-44-4;
Publication Date
19880101
Fiscal Year
1988
NTIS Accession No.
NTIS Price
Source Name
Proceedings of the Fourth NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, April 22-23, 1986, Rockville, Maryland, NIH Publication No. 88-2960
State
MD;
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