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Relationship of clearance and deposition of silica to histological and immunological changes.

Authors
Burns-CA
Source
Center for Air Environment Studies, Pennsylvania State University, State College, Pennsylvania 1978 Mar; :1-97
Link
NIOSHTIC No.
00180429
Abstract
Inbred female Balb/c-mice were exposed to silica (7631869) dust over a period of 39 weeks to study alterations of B-lymphocyte immunocompetence. At all time points following the aerosol stimulation of the mice with whole Escherichia-coli-055:B5, the thymus independent anti Escherichia-coli lipopolysaccharide (LPS) response was significantly suppressed in the spleen. In the mediastinal lymph nodes (MLN) the immune response to LPS was enhanced at 9 weeks, followed by a depression. When the silicon damaged lungs were bypassed using an intravenous injection of the antigen this response was not noted. Histological examination of silicotic lesions indicated silica laden aggregations or dust cells at 24, 33, 36, and 39 weeks. The presence of silica dust in the lungs was confirmed using energy dispersive x-ray analysis which also identified submicroscopic silica particles in the spleen. The lungs and MLNs demonstrated granulomatous and fibrotic changes at 39 weeks. Aerosol immunized lungs demonstrated perivascular and peribronchiolar lymphocytic cuffing. The bronchioles of silica exposed animals contained a greater number of macrophages. Infiltration of macrophages was noted adjacent to blood vessels and respiratory airways on scanning electron microscopy examination.
Keywords
NIOSH-Grant; Laboratory-animals; Dust-inhalation; Pulmonary-system-disorders; Lung-disease; Silica-dusts; Silicosis; Airborne-dusts
Contact
Veterinary Science Pennsylvania State University 102 Animal Industries Bldg University Park, PA 16802
CAS No.
7631-86-9
Publication Date
19780301
Document Type
Final Grant Report
Funding Amount
75435
Funding Type
Grant
Fiscal Year
1978
NTIS Accession No.
PB88-237714
NTIS Price
A06
Identifying No.
Grant-Number-R01-OH-00538
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Center for Air Environment Studies, Pennsylvania State University, State College, Pennsylvania
State
PA
Performing Organization
Pennsylvania State University Park, University Park, Pennsylvania
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