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Comparison of behavioral teratogenic effects of ethanol and n- propanol administered by inhalation to rats.

Authors
Nelson-BK; Brightwell-WS; Burg-JR
Source
Neurobehav Toxicol Teratol 1985 Nov; 7(6):779-783
NIOSHTIC No.
00180046
Abstract
The effects of inhalation of ethanol (64175) and n-propanol (71238) on reproduction were investigated using male and pregnant female Sprague-Dawley-rats. The animals were exposed to 0, 10,000, or 16,000 parts per million (ppm) ethanol or 0, 35,000 or 7,000ppm n- propanol for 7 hours/day either for a 6 week period or during the period of gestation. Exposure to 10,000 or 16,000ppm ethanol had no effect on weight gain, feed and water intake or fertility. Males exposed to 7,000ppm n-propanol demonstrated reduced fertility; no other adverse effects were noted for propanol exposure in either sex. Behavioral testing among the offspring demonstrated no differences from controls following paternal or maternal exposure to these alcohols. At the higher n-propanol concentration, several of the offspring had crooked tails. A method was given for calculating the blood alcohol content based on inhalation exposure levels. These calculated blood alcohol concentrations for the animals exposed to ethanol were close to the actual measurements of blood alcohol levels. A comparison was offered between the blood alcohol levels achieved through inhalation exposures and those attained through other exposure routes.
Keywords
NIOSH-Author; Organic-solvents; Teratogenesis; Reproductive-system-disorders; Neuropathology; Behavioral-testing; Blood-analysis; Reproductive-hazards; Laboratory-animals
CODEN
NTOTDY
CAS No.
64-17-5; 71-23-8
Publication Date
19851101
Document Type
Journal Article
Fiscal Year
1986
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0275-1380
NIOSH Division
DBBS
Source Name
Neurobehavioral Toxicology and Teratology
State
OH
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