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Pharmacokinetics of Ethoxyethanol in Humans.

Authors
Hattis-D; Berg-R
Source
Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts, Report No. CTPID 88-1, 1988 Feb:90 pages
Link
NIOSHTIC No.
00179876
Abstract
Pharmacokinetic models were developed of the uptake of ethoxyethanol (110805) (EE), metabolism of EE via ethoxyacetaldehyde to ethoxyacetic-acid (627032) (EAA), and urinary excretion of EAA. The performance of these models was tested with data on EE exposure, and preshift and postshift urinary EAA excretion/gram creatinine in a group of 36 painters studied over several successive days. Two models were constructed using only a single kinetically homogeneous body compartment for ethoxyacetaldehyde and EAA (the best estimate simplest model and the alternative simplest model). The other two models incorporated tissue compartments and diurnally varying blood flows adapted from earlier studies using perchloroethylene (the less simple model and the 70 hour model). From observations with other hydrophilic chemicals, tissue/blood partition coefficients were estimated. The less simple model resulted in a peak of urinary EAA just under 3 hours after the end of exposure and had a half time for urinary EAA excretion of 33 hours. About 42 percent of retained EE was metabolized via the aldehyde-dehydrogenase pathway. This method incorporated plausible features used in full physiologically based pharmacokinetic models, fit to the urinary EAA excretion data as well as any other and better than some models, demonstrated a later peak of EAA urinary excretion which is more in keeping with earlier studies, and performed slightly better in reconciling moles EE absorbed as calculated by other methods.
Keywords
Painting; Pharmacology; Solvents; Ethanols; Aldehydes; Humans; Kinetics; Urine-chemistry; Metabolic-study; NIOSH-Publication;
CAS No.
110-80-5; 627-03-2;
Publication Date
19880201
Fiscal Year
1988
NTIS Accession No.
PB88-221528
NTIS Price
A06
Source Name
Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts, Report No. CTPID 88-1, 90 pages, 91 references
State
MA;
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