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Walk-Through Survey Report of Burns-Biotec Laboratories, Omaha, Nebraska, Report No. IWS-131-17.

Authors
Elliott-L; Pauker-S
Source
NIOSH 1981 Apr:26 pages
Link
NIOSHTIC No.
00179838
Abstract
In efforts to understand risks to workers engaged in research with recombinant DNA processes and associated industries, a walk through survey was conducted at Burns-Biotec Laboratories (SIC-2834) near Omaha, Nebraska. At this facility, human leukocyte interferon production was carried out using recombinant DNA fermentation techniques in facilities separate from other work at the company. Six employees were assigned to the recombinant DNA project; 45 employees worked at the facility. An Institutional Bio-Safety Committee was formed in compliance with National Institutes of Health (NIH) guidelines. Environmental monitoring involved placement of agar filled settling plates around fermentation apparatus to monitor leakage of Escherichia-coli. Workers were required to report all injuries to health services and the Principal Investigator within 48 hours, including accidental inoculation, ingestion, or probable inhalation as well as lacerations and abrasions. Spills or escape of organisms containing recombinant DNA molecules were immediately reported to the safety officer. Engineering controls included fermenter exhaust gas filtration and waste product controls which were within NIH guidelines. Work practices and emergency and accident procedures were reviewed. The authors conclude that Burns-Biotec Laboratories are meeting various relevant safety issues in a responsible manner. Specific recommendations are offered concerning validation procedures, facility design, work practices, and a medical surveillance program.
Keywords
NIOSH-Author; NIOSH-Survey; Field-Study; IWS-131-17; Region-7; Medical-research; Laboratory-workers; Safety-practices; Biohazards; Accident-prevention; Deoxyribonucleic-acid-replication;
Publication Date
19810415
Fiscal Year
1981
NTIS Accession No.
PB88-221601
NTIS Price
A03
Identifying No.
IWS-131-17
NIOSH Division
DSHEFS;
SIC Code
2834;
Source Name
Division of Surveillance, Hazard Evaluations, and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, Report No. IWS-131-17, 26 pages
State
NE; OH;
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