Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Factors Influencing Biological Responses to Chemicals.

Authors
Mahaffey-KR
Source
Mechanisms of Cell Injury: Implications for Human Health 1987:315-331
Link
NIOSHTIC No.
00179559
Abstract
Factors influencing biological responses to environmental chemical exposure were examined with emphasis on biological differences in subjects that influenced susceptibility to toxic chemicals. Factors were identified as intrinsic or extrinsic. Nutritional status significantly modified host susceptibility and was associated with increased or decreased chance that chemical exposure would result in adverse health effects; the physiological basis for nutritional effects on chemical toxicity varied with both the type of contaminant and nutrient. Many of the age related differences in chemical susceptibility were associated with altered absorption, distribution, biotransformation, and/or elimination of the chemical; gastrointestinal tract absorption, lung absorption, and tissue distribution and effect were also considered. The greater vulnerability of neonates was primarily attributed to greater absorption across membranes and the developmental pattern of detoxifying enzymes. Additional host factors influencing response to chemicals included effects of concurrent exposure to other chemicals and gender of the subject.
Keywords
Risk-factors; Biological-effects; Biohazards; Environmental-exposure; Environmental-hazards; Toxic-effects; Biological-factors; Physiological-response;
Publication Date
19870101
Editors
Fowler-BA;
Fiscal Year
1987
NTIS Accession No.
NTIS Price
Source Name
Mechanisms of Cell Injury: Implications for Human Health
State
NY;
TOP