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Selective pancreatic toxicity of palmitoylpentachlorophenol.

Authors
Ansari-GA; Kaphalia-BS; Boor-PJ
Source
Toxicology 1987 Oct; 46(1):57-63
NIOSHTIC No.
00175571
Abstract
The toxicity of palmitoylpentachlorophenol (PPCP), a lipid conjugate of pentachlorophenol (87865) that has been found in human fat, was investigated in the rat. Male Sprague-Dawley-rats were given 100mg/kg PPCP in mineral-oil by gavage, and the animals were sacrificed 4, 8, or 12 days (d) after the treatment. Liver, lung, heart, spleen , kidney, testes, thyroid, pancreas, stomach, jejunum, colon, forebrain, skeletal muscle, and adrenal glands were examined histologically in routine sections stained by hematoxylin and eosin. Sections of pancreas were also stained for fibrous and elastic tissue. No gross lesions were observed at necropsy, and there was no evidence of microgranulomas. Pancreas exhibited a focal loss of pancreatic acini with replacement by clear vacuolated cells at 4 and 8d after treatment. The presence of an acute inflammatory infiltrate in the pancreas parenchyma was noted at all times. Formation of fibrous tissue by 12d resolved the loss of acinar tissue. The vascular and inflammatory lesions and the resolving fibrous lesions were mainly focal, small, and scattered. The authors conclude that PPCP has a specific target organ toxicity for exocrine pancreas and causes morphological damage to this organ.
Keywords
NIOSH-Publication; NIOSH-Grant; Chlorinated-phenols; Lipids; Laboratory-animals; In-vivo-studies; Toxicopathology; Histopathology
CODEN
TXCYAC
CAS No.
87-86-5
Publication Date
19871012
Document Type
Journal Article
Funding Amount
721590.00
Funding Type
Grant
Fiscal Year
1988
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02149
Issue of Publication
1
ISSN
0300-483X
Source Name
Toxicology
State
TX
Performing Organization
Human Biol Chem and Genetics University of Texas Med BR Dept of Human Biol Chem&gene Galveston, Tex 77550-2774
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