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A study of some biological surfactants.

Authors
Mendenhall-RM; Mendenhall-AL Jr.; Tucker-JH
Source
Ann NY Acad Sci 1966 Sep; 130(3):902-919
NIOSHTIC No.
00175525
Abstract
Using a vertical pull surface balance, comparisons were developed between static and dynamic surface tensions of lung alveolar surfactant (LAS) and other biological surfactants. Two methods of measurement were used. The first permitted each surfactant the freedom to spread beyond the confines of the barriers of the surface balance at low surface tension. In the second method such spreading was inhibited. The findings from these studies were used to further understand the role of LAS in lung mechanics and to help reconcile the difference in static surface tensions of LAS which are obtained with the surface balance and those which are reported for bubbles derived from the same material. Surface films of LAS demonstrated a marked spreading tendency and local surface turbulence. This could provide a mechanism for transport at surfaces of this type of mucus. Films of LAS may be capable of converting chemical to mechanical energy. The authors suggest that the same surface properties demonstrated for LAS should exist to a variable degree at biological interfaces in general, including other mucous surfaces. Lung stability based on surface properties of bubbles lined with LAS, lung stability based on early surface balance studies, lung alveolar surface area and breathing movements, the spread of films of LAS from lung alveoli, and factors which inhibit the spread of LAS were discussed.
Keywords
NIOSH-Author; Lung-function; Lung-cells; Alveolar-cells; Pulmonary-system; Pulmonary-function; Mucous-membranes; Surface-properties
CODEN
ANYAA9
Publication Date
19660901
Document Type
Journal Article
Fiscal Year
1966
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0077-8923
NIOSH Division
BOSH
Source Name
Annals of the New York Academy of Sciences
State
OH
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