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Regional differences in gas trapping (airway closure) between apex and base of excised rat lungs.

Authors
Morgan-JJ; Franz-GN; Frazer-DG
Source
Respir Physiol 1984 Mar; 55(3):309-316
NIOSHTIC No.
00174927
Abstract
Regional differences in gas trapping between the apex and base of the lung were assessed in excised lungs from male Long-Evans-hooded- rats. The lungs were ventilated with air as they were suspended upright, inverted in saline, or supported upright in saline, and pressure volume curves were recorded for each of the three conditions. The distribution of transpulmonary pressures over which gas trapping occurred was evaluated by statistical analysis. Increasing uniformity of gas trapping was associated with a decreasing standard deviation for the distribution of transpulmonary pressures. The standard deviations for the distribution of transpulmonary pressures under the three conditions of the study were 1.10, 0.63, and 1.57 for the lung in air, inverted in saline, and upright in saline, respectively. The authors conclude that gas trapping in lungs occurs at the base before it occurs at the apex and that gas trapping for lungs inverted in saline is more uniformly distributed from apex to base than gas trapping in lungs either upright in saline or in air.
Keywords
NIOSH-Author; In-vitro-studies; Laboratory-animals; Air-flow; Physiology; Pulmonary-function; Airway-obstruction; Lung-function; Air-pressure; Author Keywords: Airway closure; Posture; Gas distribution; Rat; Lung; Trapped gas
CODEN
RSPYAK
Publication Date
19840301
Document Type
Journal Article
Fiscal Year
1984
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0034-5687
NIOSH Division
ALOSH
Source Name
Respiratory Physiology
State
WV
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