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Current intelligence bulletin 17 - 2-nitropropane.

Authors
NIOSH
Source
NIOSH 1977 Apr; :1-6
NIOSHTIC No.
00170798
Abstract
Health hazards associated with 2-nitropropane (79469), a widely used solvent in industrial coatings and printing inks, were discussed. An inhalation study conducted in male Sprague-Dawley-rats and New- Zealand-white-rabbits showed that all rats exposed to 207 parts per million (ppm) 2-nitropropane over a 6 month period developed hepatocellular carcinomas or hepatic adenomas. Tumors were not seen in animals exposed to lower levels or for shorter times, although other liver changes were seen after 1 or 3 months exposure at the high level. Additionally, liver sections from two rats exposed to 300ppm 2-nitropropane in another study, when examined by a NIOSH pathologist, showed clear cell foci similar to those frequently seen prior to the development of hepatocellular carcinomas in rats exposed to known hepatic carcinogens. Reports concerning health effects have shown that exposure to 2-nitropropane alone or in combination with 1-nitropropane (108032) causes nausea, dizziness, headache, and diarrhea. Occupational exposure to 2-nitropropane was implicated in certain cases of liver injury. Industrial hygiene practices to reduce exposure to 2-nitropropane are presented. It is noted that NIOSH plans to conduct industrial hygiene and epidemiologic studies at facilities where 2-nitropropane is manufactured or used. The author concludes that 2-nitropropane should be handled in the workplace as if it were a human carcinogen.
Keywords
NIOSH-Author; NIOSH-Current-Intelligence-Bulletin-No-17; Nitro-compounds; Alkanes; Health-hazards; Protective-measures; Risk-analysis; In-vivo-studies; Laboratory-animals; Carcinogenesis; Liver-cancer; Toxic-effects; Occupational-exposure
CAS No.
79-46-9; 108-03-2
Publication Date
19770425
Document Type
Numbered Publication; Current Intelligence Bulletin
Fiscal Year
1977
NTIS Accession No.
PB83-105080
NTIS Price
A02
Identifying No.
(NIOSH) 78-127; CIB 17
Source Name
National Institute for Occupational Safety and Health
State
OH
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