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Mutagenic Monitoring of Workplace and Workers - Final Report.

NIOSH 1986 Dec:23 pages
In efforts to safeguard employees against occupational exposure to potential genotoxic agents, various assay systems were devised and tested. Due to the fact that short term genotoxicity studies can provide information regarding not only potential genetic hazards, but carcinogenic and teratogenic hazards as well, the establishment of these assay systems may be extremely important. Brief descriptions were offered of several studies in this area. These included: mutagenicity studies of air particles, volatile compounds and complex mixtures taken from workplace samples; the development and validation of an in-situ assay system to detect airborne mutagenic agents in the workplace; the human cytogenetic assay system which has both sister chromatid exchange and chromosome aberration endpoints; the development of a bacterial forward mutation assay system using the new tester strain (SV-50) for the Salmonella arabinose resistant forward mutation assay system; an evaluation of a urine mutagenesis assay system which has been used to determine whether workers were exposed to mutagenic agents; in- vivo and partial in-vivo cytogenetic studies to monitor human populations by collecting blood and/or bone marrow from exposed subjects and culturing cells for one or two cell cycles with various treatments in culture; and the analysis of the antimutagenic activity of chlorophyllin to determine its possible usefulness for counteracting or eliminating mutagenic and carcinogenic agents in humans.
Carcinogens; Teratogens; Mutagens; Workplace-studies; Cell-cultures; Hazardous-materials; Monitoring-systems;
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Department of Health and Human Services, NIOSH, Identification No. VKC - Ahm-110, 23 pages, 102 references