Site visits were made at two ketone production facilities, the Union Carbide facility at Institute, West Virginia, and the Tennessee Eastman facility at Kingsport, Tennessee, to observe procedures for handling these compounds. Labels and warning placecards were used in each facility. Routine use of personal protective equipment in general consisted only of eyeglasses and safety shoes. Protective aprons, coats, gloves and face shields were available as needed. Safety training and educational programs were in place at each company. Handling of ketones specifically involved primarily pipe and vessel entry, spill containment and handling, and fire fighting procedures. Preplacement and periodic medical examinations were required except for workers exposed to acetone (67641), which was considered safe. Housekeeping and sanitation facilities were in keeping with the manufacture of flammable and moderately toxic liquids. Samples of air quality were routinely taken at each facility with charcoal tube and gas chromatography methods being used. This report included flow charts of the production processes, medical examination forms, preplacement medical examination history report, examples of warning labels, information provided on the hazards of the chemicals being used, hazardous work permits, and results of air sampling tests.