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NIOSH Testimony on Formaldehyde by R. A. Lemen, May 5, 1986.

Authors
NIOSH
Source
NIOSH 1986 May:17 pages
Link
NIOSHTIC No.
00170021
Abstract
In view of animal studies indicating that formaldehyde (50000) was a carcinogen, this testimony provided evidence to support the position that exposure to formaldehyde be kept to the lowest feasible concentration possible; 0.1 part per million (ppm) in air by collection of an air sample for any 15 minute period, the lowest quantifiable detected concentration at the present time. Significant excesses of squamous cell carcinomas of the nasal cavity were found in both male and female Fischer-344-rats, in male hybrid- mice, and in male Sprague-Dawley-rats. Results of individual studies suggested a connection between formaldehyde exposure and the incidence of lung cancer, brain cancer, leukemia, and nasopharyngeal cancer. The mutagenicity of formaldehyde was demonstrated in studies on fruit-flies, grasshoppers, flowering plants, fungi, and bacteria. Evidence suggested that formaldehyde forms cross linking bonds between DNA and protein at concentrations of 6ppm and greater. Examination of workplace exposure data suggested that in most occupations formaldehyde exposures were below 0.5ppm concentration levels with only 10 percent being above 1ppm. Problems encountered using particular monitoring and respiratory protective equipment were briefly considered.
Keywords
NIOSH-Author; NIOSH-Testimony; Lemen-R-A; Garment-workers; Risk-analysis; Cancer-rates; Nasal-cancer; Carcinogens; Mutagens;
CAS No.
50-00-0;
Publication Date
19860505
Fiscal Year
1986
NTIS Accession No.
PB87-222626
NTIS Price
A03
Source Name
NIOSH, 17 pages
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