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Association of Metsovo lung and pleural mesothelioma with exposure to tremolite-containing whitewash.

Authors
Langer-AM; Nolan-RP; Constantopoulos-SH; Moutsopoulos-HM
Source
Lancet 1987 Apr; 329(8539):965-967
NIOSHTIC No.
00169702
Abstract
Asbestiform tremolite (14567738) which was used as a whitewash by the inhabitants of four small villages in northwestern Greece, was investigated. The studies were prompted after discovery during a radiological tuberculosis survey, of evidence indicating the occurrence of pleural thickening and plaques, reduced lung function, the presence of tremolite fibers in the transbronchial biopsy specimens and reported incidences of pleural mesothelioma amounting to 1 percent of total mortality among the inhabitants of the villages. The optical properties of the fibers tested were consistent with tremolite. Morphologically, they resembled short asbestos fibers. X-ray diffraction analysis of the whitewash demonstrated that it consisted primarily of tremolite, with small amounts of chlorite (1318598) and traces of magnesite (546930). Electron microscopic analysis of the fine fraction demonstrated features resembling asbestos fibers. The cytotoxic activity of the tremolite whitewash was shown to be greater than that of crocidolite (12001284) and amosite (12172735), but lower than that of chrysotile (12001295). The authors conclude that the tremolite examined appears to be responsible for the etiology of mesothelioma observed in the villages in question.
Keywords
NIOSH-Publication; NIOSH-Grant; Mineral-dusts; Lung-cancer; Toxicology; Pulmonary-system-disorders; Diagnostic-techniques; Epidemiology; Dust-analysis; Analytical-methods; Cytotoxicity
CODEN
LANCAO
CAS No.
14567-73-8; 1318-59-8; 546-93-0; 12001-28-4; 12172-73-5; 12001-29-5
Publication Date
19870425
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
1987
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-01905
Issue of Publication
8539
ISSN
0140-6736
Priority Area
Pulmonary-system-disorders
Source Name
Lancet
State
PA
Performing Organization
Industrial Environ Health Scis University of Pittsburgh 130 Desoto Street Pittsburgh, PA 15261
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