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The development and application of algorithms for generating estimates of toxicity for the NOHS data base.

Authors
Venable-HL
Source
NIOSH 1986 Jul; :1-104
Link
NIOSHTIC No.
00169481
Abstract
Computer based algorithms were developed and applied to the chemical compounds listed in the NIOSH National Occupational Hazard Survey data base to generate estimates of toxicity for these compounds for the median oral toxic dose in rats, mutagenicity, carcinogenicity, and teratogenicity potentials. All four algorithms which were developed contained the assumption that a structure/activity relationship existed among groups of compounds that exhibited similar chemical characteristics. While these algorithms did not directly address the problem of metabolism of parent compounds into other more or less toxic compounds, they did so indirectly as the toxic effects noted and reported were used as the basis for assigning a toxic or nontoxic status to the parent compound. These algorithms did not consider site of toxic effect, type of cancer, or the actual cause of death in the case of the median lethal dose (LD50) algorithm. The author concludes that these models can serve as tools for investigating the potential toxicity of compounds, although they cannot be used in place of animal test data.
Keywords
NIOSH-Author; Carcinogens; Mutagens; Teratogens; Data-processing; Toxic-effects; Toxic-materials
Publication Date
19860701
Document Type
Numbered Publication
Fiscal Year
1986
NTIS Accession No.
PB87-205639
NTIS Price
A07
Identifying No.
(NIOSH) 87-101
NIOSH Division
DSHEFS
Source Name
National Institute for Occupational Safety and Health
State
OH
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