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Organophosphorus ester-induced delayed neurotoxicity.

Authors
Abou-Donia-MB
Source
Annu Rev Pharmacol Toxicol 1981 Apr; 21:511-548
NIOSHTIC No.
00168204
Abstract
The relationship between the chemical structure of organophosphorus esters and their ability to induce delayed neurotoxicity is reviewed. The biochemical target as well as factors affecting the development of organophosphorus ester induced delayed neurotoxicity (OPIDN) are discussed. Specific topics covered include the development of an experimental model of delayed neurotoxicity (with provision for species selectivity, age sensitivity, stages of delayed neurotoxicity in chickens, and factors affecting the development of delayed neurotoxicity), mechanisms of delayed neurotoxicity (as they relate to histopathological studies, cell bodies, central nervous system, peripheral nerves, peripheral sensory nerves, neuromuscular junctions, and muscle), electrophysiological studies, and biochemical studies (including the inhibition of esterases, theory of neurotoxic esterase, significance of inhibition of nonspecific esterases, effect on acid-phosphatase activity, and effect on axoplasmic transport). The site of neurotoxic action is reviewed with specific mention made of chemical structure relationships to delayed neurotoxic activity for aliphatic phosphorus esters, pyrophosphorus esters, aliphatic aromatic phosphorus esters, triaryl phosphate esters, and saligenin cyclic phosphorus esters. A working hypothesis of the mode of action of OPIDN is presented.
Keywords
NIOSH-Publication; NIOSH-Grant; Nervous-system-disorders; Phosphorus-compounds; Cholinesterase-inhibitors; Organic-compounds; Acetylcholinesterase; Age-factors; Insecticides; Agricultural-chemicals; Neurotoxic-effects
CODEN
ARPTDI
Publication Date
19810401
Document Type
Journal Article
Funding Amount
1567389
Funding Type
Grant
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00823
ISSN
0362-1642
Priority Area
Neurotoxic-effects
Source Name
Annual Review of Pharmacology and Toxicology
State
NC
Performing Organization
Pharmacology Duke University Department of Pharmacology Durham, N C 27710
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