Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The chronic health effects of occupational exposure to dioxin: unanswered questions.

Authors
Moody-L; Halperin-WE; Fingerhut-MA; Landrigan-PJ
Source
Am J Ind Med 1984; 5(3):157-160
NIOSHTIC No.
00168025
Abstract
The chronic health effects of occupational exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) (TCDD) are discussed. Concern about delayed toxic effects that could result from exposure to TCDD is widespread, since a variety of groups have been exposed to it. TCDD is formed during the synthesis of 2,4,5-trichlorophenoxyacetic- acid from trichlorophenol. It is also generated when trichlorophenol is synthesized from tetrachlorobenzene. Acute toxicity studies have shown that TCDD is lethal to some species at concentrations below 1 microgram per kilogram. TCDD has been found to be teratogenic and fetotoxic in female mice and carcinogenic in rats and mice. Preliminary data collected by NIOSH suggest a possible association between occupational exposure to TCDD and an increased number of deaths from soft tissue sarcoma. Many epidemiologic studies have indicated that there is a range of toxic effects associated with TCDD exposure in humans, especially heavily exposed workers. Chloracne, signs of hepatotoxicity such as porphyria and metabolic and lipid abnormalities (including elevated triglyceride concentrations), neurotoxicity, and immunologic changes have been observed. Except for chloracne, the persistence of each of these findings requires confirmation. Other studies have given conflicting data about a possible association between TCDD exposure and heart disease. The authors recommend that additional studies on immunologic, hepatic, neurologic, and reproductive consequences of exposure to TCDD be conducted and that the question regarding human carcinogenicity of TCDD be resolved.
Keywords
NIOSH-Author; Organo-chlorine-compounds; Health-hazards; Environmental-hazards; Chlorinated-hydrocarbons; Epidemiology; Toxic-effects; Biological-effects; Industrial-exposures; Environmental-exposure; Carcinogenesis
CODEN
AJIMD8
CAS No.
1746-01-6
Publication Date
19840101
Document Type
Journal Article
Fiscal Year
1984
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
TOP