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Neuropathological effects of phenyl saligenin phosphate in chickens.

Authors
Jortner-BS; Ehrich-M
Source
Neurotoxicology 1987 Jan; 8(1):97-108
NIOSHTIC No.
00167059
Abstract
The pathogenesis of organophosphate ester induced delayed neuropathic effects was investigated in chickens treated with phenyl- saligenin-phosphate (4081236) (PSP) or with tri-ortho-tolyl- phosphate (78308) (TOTP). Adult White-Leghorn-chickens were administered intramuscular injections of 2, 3, or 10mg/kg PSP, or were orally administered 360 or 500mg/kg TOTP. Ataxia and weakness were observed after exposure to either compound. Neuropathy target esterase was decreased by more than 85 percent by 24 hours after exposure, but this returned to control values after 2 weeks. Electron microscopy revealed qualitatively similar lesions secondary to PSP and TOTP administration. Injuries of the distal regions of large myelinated axons in long spinal cord tracts and peripheral nerves were observed. The peripheral nerve lesions were characterized by intraaxonal collections of mitochondria, dense and lamellar bodies, and granular degeneration of neurofilaments. These lesions progressed to Wallerian like degeneration. The authors conclude that there is a significant correlation between the percentage of injured nerve fibers and the severity of clinical symptoms.
Keywords
Neurotoxicity; Phosphates; Neuropathy; Nerve-damage; Esters; Nerve-fibers; Histopathology; Laboratory-animals
CODEN
NRTXDN
CAS No.
4081-23-6; 78-30-8
Publication Date
19870101
Document Type
Journal Article
Fiscal Year
1987
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0161-813X
Source Name
Neurotoxicology
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