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In-Depth Survey Report: Control Technology Assessment of Enzyme Fermentation Processes at Novo Biochemical Industries, Inc., Franklinton, North Carolina, CT-116-15b.

Authors
Martinez-KF
Source
NIOSH 1986 Dec:37 pages
Link
NIOSHTIC No.
00166586
Abstract
An in depth survey was made of the Novo Biochemical Industries, Inc. (SIC-2869) (NBI) facility located in Franklinton, North Carolina to evaluate the controls and containment capabilities employed in their alpha-amylase enzyme manufacturing process. The process at the facility used a strain of Bacillus-licheniformis to produce alpha- amylase. Possible hazardous exposures at the facility included hazardous microorganisms, toxic processing chemicals, and biologically active products or intermediates. Viable air samples collected from background locations contained concentrations ranging from 120.8 colony forming units/cubic meter (CFU/m3) for the outside samples to 271.2CFU/m3 around the aging tanks. Viable samples collected around selected unit processes ranged from 3.2CFU/m3 in the clean rooms to 705.7CFU/m3 at the sample port. Total dust levels ranged from 0.07mg/m3 at the fermentor tank agitator shaft to computer controlled and monitored process technology which limits direct employee involvement and potential hazard exposure. Potential exposures in the laboratory process, fermentation process, and recovery process steps are considered and NBI's work practices, environmental health monitoring program, and personal protection requirements are discussed. The author concludes that the results of the viable air sample analysis indicate an effective system of control measures.
Keywords
NIOSH-Author; NIOSH-Survey; Field-Study; CT-116-15b; Region-4; Microorganisms; Enzyme-activity; Bacteria; Biological-material;
Publication Date
19861201
Document Type
Field Studies; Control Technology
Fiscal Year
1987
NTIS Accession No.
PB87-174082
NTIS Price
A04
Identifying No.
CT-116-15b
NIOSH Division
DPSE;
SIC Code
2869;
Source Name
Division of Physical Sciences and Engineering, NIOSH, Cincinnati, Ohio, Report No. CT-116-15b, 37 pages, 10 references
State
NC; OH;
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