Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Information Profiles on Potential Occupational Hazards: Adipic Acid.

Authors
Anonymous
Source
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-519 1981 Mar:22 pages
Link
NIOSHTIC No.
00166583
Abstract
Information on potential occupational hazards from exposure to adipic-acid (124049) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. Production of adipic-acid was 1.8 million pounds in 1979; most of this was used in the production of nylon-66 fibers. Other uses included the production of nylon-66 resins, nylon-66 plastics, as a hexamethylenediamine precursor, in polyurethane resins and plasticizers, and as a food additive. To a much smaller extent adipic-acid was used in insecticides, adhesives, tanning and leather dyes, textile printing, and textile softening. Administration of adipic acid to experimental animals has produced patchy livers, irritation of organs directly exposed, hemorrhagic lungs and symptoms of acidosis. A median lethal dose of 940mg/kg was established for adult male rats. Subchronic exposures in rats produced symptoms of toxicity including depression, dyspnea, ataxia, and convulsions. No significant evidence for carcinogenicity has been reported nor has there been any finding of mutagenicity or teratogenicity or any reproductive effects. No evidence of toxicity was found on oral administration of 100mg/kg adipic-acid per day to human subjects.
Keywords
NIOSH-Contract; Contract-210-79-0030; Plastics-industry; Textiles-industry; Chemical-manufacturing-industry; Chemical-industry-workers; Agricultural-chemicals; Occupational-exposure;
CAS No.
124-04-9;
Publication Date
19810301
Funding Type
Contract;
Fiscal Year
1981
NTIS Accession No.
PB87-174322
NTIS Price
A03
Identifying No.
Contract-210-79-0030
Source Name
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-519
State
NY;
TOP