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Developmental neurotoxicology of in utero exposure to industrial solvents in experimental animals.

Authors
Nelson-BK
Source
Neurotoxicology 1986 Jan; 7(2):441-448
NIOSHTIC No.
00165221
Abstract
Literature was reviewed on the developmental neurotoxicity of the following industrial solvents after exposure in-utero: carbon- disulfide (75150), chloroform (67663), formaldehyde (50000), glycol- ethers, methyl-chloroform (71556), methyl-n-butyl-ketone (591786), methylene-chloride (75092), perchloroethylene (127184), n-propanol (71238), and tertiary-butanol (75650). All of these solvents were administered during pregnancy, and functional testing was carried out on the offspring. Species of test animal, dose, route and time of exposure, and the postnatal functions evaluated were presented, as well as observed effects. Although comparatively few solvents have been evaluated for developmental neurotoxicology, most of these solvents produced significant differences from controls in animals. Many studies used the inhalation route of exposure, which is the route most often encountered in occupational or environmental exposure. Most studies extended the exposure for the majority of gestation of rats. Additional testing of industrial solvents was strongly recommended.
Keywords
NIOSH-Author; Teratogenicity; Transplacental-exposure; Organic-solvents; Neurotoxic-effects; Fetus; Laboratory-animals; Behavioral-testing
CODEN
NRTXDN
CAS No.
75-15-0; 67-66-3; 50-00-0; 71-55-6; 591-78-6; 75-09-2; 127-18-4; 71-23-8; 75-65-0
Publication Date
19860101
Document Type
Journal Article
Fiscal Year
1986
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0161-813X
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Neurotoxicology
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