The effects of tris(2,3-dibromopropyl)phosphate on the reproductive system of male rats.
J Amer Coll Toxicol 1986; 5(2):153-160
Adult male Sprague-Dawley-rats were studied to determine the amounts of tris(2,3-dibromopropyl)phosphate (126727) (TRIS) required to produce significant effects on spermatogenesis, to examine other organs of the male reproductive tract for effects of TRIS, and to examine possible mechanisms for TRIS reproductive toxicity. A dose dependent decrease in body weight was observed after injection of vesicles, and epididymis decreased significantly in a dose dependent manner. Prostate weight also decreased significantly. Histological changes were noted in some seminferous tubules. In a dose dependent manner, sperm production by the testes was reduced, as well as sperm content of the epididymal tail. The percentage of motile sperm and the motility index were also affected. Serum testosterone levels and the in-vitro testicular capacity for testosterone secretion were not affected. Results suggested that TRIS does not affect reproductive endocrinology. The authors suggest that shrinkage of the testes resulted from diminished sperm production.
Laboratory-animals; In-vivo-studies; Flame-retardants; Reproductive-system-disorders; Toxic-effects; Histopathology; Endocrine-system; Microscopic-analysis; Hormones; Phosphates; NIOSH-Grant; NIOSH-Publication
Journal of the American College of Toxicology
Johns Hopkins University 4800 Atwell Road Shady Side, MD 20764