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Tissue distribution of 14C-labeled ethylene dibromide in the guinea pig.

Authors
Plotnick-HB; Conner-WL
Source
Res Commun Chem Pathol Pharmacol 1976 Feb; 13(2):251-258
Link
NIOSHTIC No.
00164422
Abstract
Male Hartley-guinea-pigs were exposed to ethylene-dibromide (EDB) (106934) as a single intraperitoneal injection of 30 milligrams/kilogram (mg/kg) body weight in order to determine EDB tissue distribution. The animals were sacrificed at 4, 8, 12, 24, 48, or 72 hours following exposure. The kidneys, liver and adrenal glands recorded the highest levels of contamination. Kidneys recorded 286.64, 236.52, 247.79, 73.45, 14.66, and 10.47 micrograms EDB/gram (microg/g) of tissue at 4, 8, 12, 24, 48, and 72 hours, respectively. Liver concentrations for the same time periods were 129.03, 104.91, 78.39, 38.07, 16.20, and 15.58 microg/g. Adrenal gland concentrations were 60.73, 60.82, 25.56, 28.63, 13.24, and 10.43microg/g. Sixty-six percent of the administered dose was excreted through the urinary tract. Excretion in the feces was insignificant. About 10 to 12 percent of the administered dose may have been excreted in the exhaled air. The pattern of EDB distribution in the tissues as determined in this study is completely consistent with earlier studies of the pathologic changes brought about through exposure to this compound. The authors conclude that since inhalation appears to be the most likely route for human exposure both occupationally and environmentally, the carcinogenic potential of EDB should be assessed by utilizing the inhalation route.
Keywords
Fumigants; Grain-dusts; Brominated-hydrocarbons; Inhalants; Kidney-damage; Liver-damage; NIOSH-Author
CODEN
RCOCB8
CAS No.
106-93-4
Publication Date
19760201
Document Type
Journal Article
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0034-5164
Source Name
Research Communications in Chemical Pathology and Pharmacology
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