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Health hazard evaluation report: HETA-81-385-1659, Texaco Chemical Company, Port Neches, Texas.

Authors
Meinhardt-TJ
Source
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HETA 81-385-1659, 1986 Feb; :1-17
NIOSHTIC No.
00163147
Abstract
Following a request made by the Oil, Chemical and Atomic Workers Union, genotoxicity associated with occupational exposures to ethylene-oxide (75218) at the Texaco Chemical Company (SIC-2810), Port Neches, Texas, was evaluated. Blood and industrial hygiene samples were collected. The annual mean exposure to ethylene-oxide in the production departments had been 1.73 parts per million (ppm) or less during the period from 1978 through 1982 with short-term peak exposures over 100ppm. Analyses of the chromosomal aberrations (CA) and sister chromatid exchange (SCE) data suggest that the exposures appear to produce marginally significant increases in the group mean SCE frequency per chromosome per cell in nonsmokers compared to control nonsmokers. The author concludes that these exposures are not associated with an overwhelming increase in genotoxicity effect. Significant elevations observed in both the group mean SCE frequency per chromosome per cell and in group mean transformed CA frequency of lab workers compared to those frequencies observed in referents can not be attributed solely to ethylene-oxide due to the complex nature of this working environment. As a potential occupational carcinogen, exposure to ethylene oxide is to be reduced to the lowest extent possible.
Keywords
NIOSH-Publication; NIOSH-Health-Hazard-Evaluation; HETA-81-385-1659; Carcinogens; Mutagens; Ethylenes; Oxides; Chromosome-disorders; Chemical-manufacturing-industry; Genetic-disorders; Region-6; Hazard-Unconfirmed; NIOSH-Technical-Assistance-Report; Author Keywords: Chemical Manufacturing; ethylene oxide; chromosomal aberrations; sister chromatid exchange; genotoxicity; laboratory workers; chemical workers
CAS No.
75-21-8
Publication Date
19860201
Document Type
Field Studies; Hazard Evaluation and Technical Assistance
Fiscal Year
1986
NTIS Accession No.
PB86-221579
NTIS Price
A03
Identifying No.
HETA-81-385-1659
NIOSH Division
DSHEFS
SIC Code
2810
Source Name
National Institute for Occupational Safety and Health
State
TX; OH
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