Cytogenetic Study Of Workers Exposed To Ethylene Oxide: Analysis Of The Sister Chromatid Exchange Assay Data With A Discussion Of Occupational Exposure Data.
Meinhardt-T; Carrano-A; Moore-D; Ashworth-L; Marlow-D
NIOSH 1985 Dec:74 pages
A survey of sister chromatid exchange (SCE) incidence among workers occupationally exposed to ethylene-oxide (75218) was conducted. The effects of smoking were also investigated. The cohort consisted of 44 workers in ethylene-oxide production units and 27 workers in a quality assurance laboratory having exposure to ethylene-oxide and other chemicals. The comparisons consisted of 42 individuals having no exposure to chemicals. Smoking status of the subjects was determined. Circulating lymphocytes were obtained from the subjects and assayed for SCEs. Personal ethylene-oxide exposures were measured. Median exposures to ethylene-oxide were 0.19 to 1.0 part per million (ppm) in the production workers and 0.14 to 10.9ppm in the laboratory workers. Cigarette smoking comparisons had a higher statistically significant incidence of SCEs than nonsmokers. Nonsmoking production workers had a marginally statistically significant elevation of SCEs compared to smoking comparisons. Cigarette smoking production workers had an insignificant excess incidence of SCEs. SCE incidence was statistically significantly increased in smoking and nonsmoking laboratory workers. The authors conclude that the data suggests an additive relationship between the effect of cigarette smoking and employment in ethylene-oxide production units. The effects of smoking and employment in the laboratory are less than additive.
NIOSH-Author; Toxic-effects; Chromosome-disorders; Occupational-exposure; Cigarette-smoking; Laboratory-workers; Human-studies; Genetic-factors; Workplace-studies; Exposure-levels;
NTIS Accession No.
Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 74 pages, 54 references