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Particle Contents Of Human Lungs.

Stettler-LE; Platek-SF; Groth-DH; Green-FH; Vallyathan-V
Proceedings of the 43rd Annual Meeting of the Electron Microscopy Society of America 1985:116-119
A survey of the particle content of human lungs was conducted. Tissue specimens from the left lung of 96 deceased residents of the Cincinnati, Ohio area were obtained. The ages of the subjects ranged from 23 to 96 years, median age 66 years. These were to be analyzed by scanning electron microscopy and energy dispersive X-ray analysis to create a set of baseline data for typical urban lungs with which comparisons of the particle contents of diseased lungs could be made. Preliminary results from 35 lung samples were presented. Exogenous particle concentrations ranged from 107 to 1,610 million particles per gram dry tissue. The median circular area equivalent diameter of the particles ranged from 0.38 to 0.89 micron. Particles classified as silica, aluminum silicates, iron- oxide like, and rutile like accounted for approximately 75 percent of the exogenous particles. Aluminum silicates accounted for the largest percentage of particles in 31 of the 35 lungs. Exogenous particle data from subjects with occupational lung disease, silicosis and coal workers pneumoconiosis were also presented. For the silicotic lungs, the silica concentrations were 17 to 75 times higher than in urban lungs. The authors note that the lungs thus far analyzed are typical for subjects from an urban area who have terminal illnesses. There is a distinction between urban lungs and normal lungs. Urban lungs are not normal since disease processes are present within them. In most cases, however, these disease processes are typical considering the age and health of the subjects.
Lung-function; Analytical-models; Humans; Air-monitoring; Respiration; Ventilation; Exposure-methods; Pulmonary-clearance; Air-sampling; Inhalants;
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Proceedings of the 43rd Annual Meeting of the Electron Microscopy Society of America