An evaluation of reports of dioxin exposure and soft tissue sarcoma pathology in U.S. chemical workers.
Fingerhut-MA; Halperin-WE; Honchar-PA; Smith-AB; Groth-DH; Russell-WO
Biological Mechanisms of Dioxin Action, Banbury Report No. 18, Poland 1984:461-470
An epidemiological study of the relationship between dioxin (125304) exposure and soft tissue sarcoma was conducted in chemical workers. Employment records, medical and pathological reports, tissue specimens, and death certificates were obtained for seven workers. The potential for exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016), 2,4,5-trichlorophenoxyacetic-acid (93765) (TPA), or trichlorophenol (25167822) (TCP) was evaluated by an examination of death certificates for six deceased persons. Medical records from hospitals and employers were obtained for evaluating the prevalence of soft tissue sarcoma. The tissue specimens were examined in two independent reviews by pathologists with expertise in the area of soft tissue sarcoma. All seven individuals had received a diagnoses of soft tissue sarcomas by their original pathologists; five of the cases were diagnosed as soft tissue sarcoma by each of the two reviewers. The original pathologists and two reviewers all agreed that five individuals had soft tissue sarcomas whereas they agreed on the histological sub type in only two individuals. Of the six deceased cases, four had notations of soft tissue sarcoma on their death certificates; all six deceased individuals and the surviving patient had hospital diagnoses of soft tissue sarcoma. Company medical records for the seven individuals indicated that three cases had records of diagnosed chloracne. Three cases were production workers assigned to the TCP or TPA department. The authors suggest that the use of death certificates alone is inadequate for the evaluation of soft tissue sarcoma outcome.
Physiological-measurements; Biological-effects; Herbicides; Biology; Exposure-limits; Chlorinated-hydrocarbons; Exposure-levels; Analytical-models; Toxicology; Workers; Tissue-disorders
125-30-4; 1746-01-6; 93-76-5; 25167-82-2
Biological Mechanisms of Dioxin Action, Banbury Report No. 18, Poland