Recommendations for a vinyl-acetate (108054) exposure and control standard are given and material employed to determine the standard is reviewed. It is recommended that exposure to vinyl-acetate in the workplace shall be controlled so that employees are not exposed to concentrations greater than 15 milligrams per cubic meter or 4 parts per million, measured as a ceiling concentration in samples collected during any 15 minute period. Recommendations are also made regarding medical surveillance, labeling and posting, personal protective clothing and equipment, informing employees of vinyl- acetate hazards, engineering controls, emergency procedures, storage, sanitation, and monitoring and record keeping requirements. Studies of biologic effects of exposure on humans, including historical reports and epidemiologic studies, are examined. Animal toxicity and metabolism research is also reviewed. Data on carcinogenicity, mutagenicity, teratogenicity, and effects on reproduction are examined; however, it is noted that little material is available on these subjects. Environmental concentrations and sampling methods are discussed. Hazard control by process and design engineering is considered. Work practices involving storage, handling and use, equipment maintenance, general housekeeping, and emergency procedures are examined. Respiratory protection and the use of other protective equipment is discussed. Research needs concerning vinyl-acetate exposure, and epidemiology and toxicity studies are described. Appended is a description of an analytical gas chromatographic method for vinyl-acetate and a material safety data sheet with an explanation of the information required to complete it.