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Terminal progress report: lead - its renal handling, renin, and erythropoietin.

Authors
Vander-AJ
Source
University of Michigan, Ann Arbor Michigan 1983 Jan; :1-3
Link
NIOSHTIC No.
00150844
Abstract
The purposes of the project were to determine whether chronic lead (7439921) exposure caused permanent changes in the renin/angiotensin system and to investigate the mechanisms for handling of leaf and other trace metals, especially zinc (7440666), by the kidney. The offspring of pregnant, lactating rats when both were exposed to 100 micrograms per milliliter lead in their drinking water developed hypertension that persisted for 6 months. The hypertension was associated with low plasma concentrations of renin and angiotensin, strongly indicating that the hypertension was not due to hyperactivity of the renin/angiotensin system. Lower doses of lead, 5 and 25 parts per million (ppm), did not induce hypertension, but caused dose dependent elevations of plasma renin. Additional experiments in lead exposed, non hypertensive rats and rabbits indicated that renin secretion was the cause of increased plasma renin. Chronic treatment of dogs and rats with up to 500ppm lead inhibited tubular reabsorption of zinc, resulting in increased urinary excretion of zinc. This was associated with significant decreases in plasma zinc concentrations.
Keywords
NIOSH-Grant; Trace-metals; Renal-absorption; Hormone-activity; Lead-fumes; Excretion; Trace-metals; Animal-studies; Exposure-methods; Enzymes
CAS No.
7439-92-1; 7440-66-6
Publication Date
19830101
Document Type
Final Grant Report
Funding Amount
243305
Funding Type
Grant
Fiscal Year
1983
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00913
NIOSH Division
OEP
Priority Area
Other Occupational Concerns; Grants-other
Source Name
University of Michigan, Ann Arbor Michigan
State
MI
Performing Organization
University of Michigan at Ann Arbor, Ann Arbor, Michigan
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