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Pulmonary function evaluation of cats after one year of exposure to diesel exhaust.

Pepelko-WE; Mattox-J; Moorman-WJ; Clark-JC
Health effects of diesel engine emissions: proceedings of an international symposium, December 3-5, 1979. Pepelko WE, Danner RM, Clarke NA, eds. Cincinnati, OH: U.S. Environmental Protection Agency, EPA-600/9-80-057b, 1980 Nov; 2:757-765
The effects of diesel exhaust emissions upon pulmonary function were studied in cats. Young adult male cats were exposed to diesel particulates at a concentration of 6 milligrams per cubic meter 8 hours per day, 7 days per week for 1 year. After 1 year, the animals were removed from the chamber and pulmonary function tests were conducted. Pulmonary function parameters evaluated included lung volume, forced expiratory flow rates, dynamic compliance and resistance, diffusing capacity, and nitrogen washout. No significant changes in pulmonary function parameters were detected except for a decrease in closing volume. The authors note that the decrease in closing volume cannot be interpreted as an impairment, as it indicates improved function of the small airways. The effect is probably a statistical error, arising from the large inter/animal variation seen in some of the pulmonary function tests. The authors conclude that inhalation of diesel exhausts under the experimental conditions does not cause functional changes in the lungs of cats. The exposed cats may have functionally adapted to the exposure.
Environmental-health-monitoring; Health-standards; Environmental-pollution; Exposure-levels; Exhaust-systems; Respiration; Lung; Physiology; Pulmonary-congestion; Inhalants; Animal-studies
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Conference/Symposia Proceedings
Pepelko-WE; Danner-RM; Clarke-NA
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Health effects of diesel engine emissions: proceedings of an international symposium, December 3-5, 1979